Harvard Ophthalmology Metabolomics in Retina Program
HOMeR Program
About AMD
Age-Related Macular Degeneration (AMD) is a multifactorial disease and is the leading causes of severe visual impairment among people over the age of 50 yrs. The pathogenesis of causation and progression of the disease is not fully understood. This has led to lack of easily accessible biomarkers for both diagnosis and prognosis, as well as lack of treatment for the early and intermediate forms of the disease.
Metabolomics
Metabolomics is the study of small molecules (<1KD) in our body. These are the end result of the genetic, transcriptomic and proteomic processes in our body and are also affected by the environmental, diet and lifestyle influences. Metabolomics have helped understand the pathogenesis of several multifactorial diseases.
Mission of our Research:
1. Understanding the molecular mechanisms of Age-Related Macular Degeneration and its progression.
2. Identifying accessible biofluid biomarkers of AMD and its progression.
3. Finding a relevant classification system for AMD using multiomics and retinal imaging
4. Identifying novel therapeutic targets for early and intermediate AMD.
